Globalization, Crop Choice and Property Rights in Rural Peru, 1994-2004

This paper describes the results of initial work analysing a panel of rural households in Peru between 1994 and 2004 to determine household responses to changes in relative prices of traditional versus export-oriented products. Our principal interest was to better understand how household responses to external economic shocks influenced rural welfare, income distribution and poverty. Since a large percentage of Peruvians living in poverty are located in rural areas, learning more about how these households respond to a changing external environment provides insights into the factors that influence their ability to improve their absolute and relative economic position. The results of our analysis indicate that changes in relative prices had a significant impact on the adoption of new agricultural products, and the magnitude of response was mitigated by households? degree of tenure security and access to regional and local markets. Analyses of household expenditures over the period indicate that those who adopted export crops experienced a significant growth in consumption proportional to the change in acreage devoted to exportable products, and were less likely to be classified as impoverished at the end of the period. Instrumental variables estimates suggest that this association is causal.agricultural households, microeconomic, international trade, structural adjustment, technology adoption, poverty,

Alien Registration- Field, Alfred J. (Mars Hill, Aroostook County)

https://digitalmaine.com/alien_docs/34219/thumbnail.jp

Empirical Legal Studies Before 1940: A Bibliographic Essay

The modern empirical legal studies movement has well-known antecedents in the law and society and law and economics traditions of the latter half of the 20th century. Less well known is the body of empirical research on legal phenomena from the period prior to World War II. This paper is an extensive bibliographic essay that surveys the English language empirical legal research from approximately 1940 and earlier. The essay is arranged around the themes in the research: criminal justice, civil justice (general studies of civil litigation, auto accident litigation and compensation, divorce, small claims, jurisdiction and procedure, civil juries), debt and bankruptcy, banking, appellate courts, legal needs, legal profession (including legal education), and judicial staffing and selection. Accompanying the essay is an extensive bibliography of research articles, books, and reports

Initial Public Offerings and the Firm Location

The firm geographic location matters in IPOs because investors have a strong preference for newly issued local stocks and provide abnormal demand in local offerings. Using equity holdings data for more than 53,000 households, we show the probability to participate to the stock market and the proportion of the equity wealth is abnormally increasing with the volume of the IPOs inside the investor region. Upon nearly the universe of the 167,515 going public and private domestic manufacturing firms, we provide consistent evidence that the isolated private firms have higher probability to go public, larger IPO underpricing cross-sectional average and volatility, and less pronounced long-run under-performance. Similar but opposite evidence holds for the local concentration of the investor wealth. These effects are economically relevant and robust to local delistings, IPO market timing, agglomeration economies, firm location endogeneity, self-selection bias, and information asymmetries, among others. Findings suggest IPO waves have a strong geographic component, highlight that underwriters significantly under-estimate the local demand component thus leaving unexpected money on the table, and support state-contingent but constant investor propensity for risk

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Alien Registration- Field, Alfred J. (Mars Hill, Aroostook County)

https://digitalmaine.com/alien_docs/34219/thumbnail.jp

Globalization, Crop Choice and Property Rights in Rural Peru, 1994-2004

This paper describes the results of initial work analyzing a panel of rural households in Peru between 1994 and 2004 to determine household responses to changes in relative prices of traditional versus export-oriented products. Our principal interest was to better understand how household responses to external economic shocks influenced rural welfare, income distribution and poverty. Since a large percentage of Peruvians living in poverty are located in rural areas, learning more about how these households respond to a changing external environment provides insights into the factors that influence their ability to improve their absolute and relative economic position. The results of our analysis indicate that changes in relative prices had a significant impact on the adoption of new agricultural products, and the magnitude of response was mitigated by households’ degree of tenure security and access to regional and local markets. Analysis of household expenditures over the period indicate that those who adopted export crops experienced a significant growth in consumption proportional to the change in acreage devoted to exportable products, and were less likely to be classified as impoverished at the end of the period. Instrumental variables estimates suggest that this association is causal.Economic

Property rights and crop choice in rural Peru, 1994-2004

The period of 1994 to 2004 was one in which rural households in Peru experienced dramatic changes in ownership rights through a large nation-wide land titling program and a significant opening of the economy to international trade. This paper takes this prime opportunity to examine whether lack of ownership rights presents a significant barrier to the adoption of commercial crops and/or modern farming practices as a result to changes which reduced domestic market distortions, opened up the economy and thereby presumably altered relative prices between traditional agricultural crops and those produced primarily for export. To the extent that participation was quasi-exogenous to other household features influencing production choices, the titling program serves as a natural experiment in tenure status by enabling us to compare the influence of price incentives across untitled and newly titled rural households. The econometric results confirmed that changes in these relative prices increased the likelihood that households would shift production towards these new export products. These tendencies appear to be strengthened if the household obtained title to their property over the period, which indicates that weak property institutions may inhibit the degree to which households can reap the benefits of a globalize market place. Moreover, our results indicated high returns to adoption of export products and that households which began producing an export oriented crop over the period were much less likely to be classified as impoverished in 2004. The obvious implication is that those who were unable to alter production due to reasons such as geographical location, access to credit, or lacking title to their property continued to produce traditional crops and were not able to escape poverty. This finding reaffirms the idea that liberalizing markets must be accompanied by appropriate social programs or institutional reforms directed to the unique situational problems of different subgroups in poverty if the broader poverty issue is to be improved